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https://scholarbank.nus.edu.sg/handle/10635/12886
DC Field | Value | |
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dc.title | Quorum sensing signal interference within and across the kingdoms | |
dc.contributor.author | YANG FAN | |
dc.date.accessioned | 2010-04-08T10:28:07Z | |
dc.date.available | 2010-04-08T10:28:07Z | |
dc.date.issued | 2008-12-03 | |
dc.identifier.citation | YANG FAN (2008-12-03). Quorum sensing signal interference within and across the kingdoms. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/12886 | |
dc.description.abstract | Quorum sensing (QS) is known to be widespread in prokaryotic world for regulating numerous important biological activities. Consequently, anti-QS approaches have recently been proposed as a promising strategy for development of novel antimicrobial agents by uncoupling bacterial QS. In this study, I explored further on the QS signal interference within and across the kingdoms. The microbial diversity in multi-species biofilms was inspected and both QS signal producing and degrading bacterial species were identified. A putative QS inhibitor (PAi), isolated from Pseudomonas aeruginosa has been purified and characterized as 2-amino-4-methoxy-but-3-enoic acid. The molecular mechanisms of PAi production were also investigated. A novel enzymic anti-QS mechanism was identified from eukaryotic kingdom. Further analysis revealed that mammalian sera possess a widely conserved catalytic mechanism different from bacterial AHL-lactonase, although they share a similar function in degrading QS signals. | |
dc.language.iso | en | |
dc.subject | quorum sensing; signal interference; acyl-homoserine lactone; AHL-lactonase; Pseudomonas aeruginosa; paraoxonase | |
dc.type | Thesis | |
dc.contributor.department | CIVIL ENGINEERING | |
dc.contributor.supervisor | HU JIANGYONG | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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yf-thesis2008.pdf | 1.87 MB | Adobe PDF | OPEN | None | View/Download |
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