Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/12885
Title: The roles of biologically active gasotransmitters (NO and H2S) in myocardial ischemia-reperfusion
Authors: FU YILONG
Keywords: NO H2S REPERFUSION INJURY HEART RAT
Issue Date: 26-Nov-2008
Source: FU YILONG (2008-11-26). The roles of biologically active gasotransmitters (NO and H2S) in myocardial ischemia-reperfusion. ScholarBank@NUS Repository.
Abstract: In the present study, we applied the NO-slow-releasing derivatives of Nonsteroidal Anti-Inflammatory Drug (NO-NSAIDs, e.g. NO-Aspirin and NO-Paracetamol) to investigate the cardioprotective effect of NO donor and the possible mechanism(s) involved. Moreover, we also investigated the time course of H2S production and its possible role in the rat model of MI/R. These findings would support the notion that increased NO availability is a useful pharmacological intervention that limits tissue injury in MI/R. In addition, our results suggest that H2S is likely to play a pro-inflammatory role in determining the severity of reperfusion injury in the rat model of MI/R. we propose that the appropriate dose of NO/H2S donor or inhibitor should be administered at appropriate time of myocardial ischemia reperfusion. The new information regarding the roles of NO and H2S in myocardial ischemia-reperfusion could deepen our understanding of mechanisms of reperfusion injury.
URI: http://scholarbank.nus.edu.sg/handle/10635/12885
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