Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/128795
Title: DESIGN OF POLYMERIC MICELLAR NANOCOMPLEXES COMPOSED OF GREEN TEA CATECHIN DERIVATIVES FOR CANCER THERAPY
Authors: NUNNARPAS YONGVONGSOONTORN
Keywords: Polymeric micellar nanocomplexes, drug delivery, green tea catechin, epigallocatechin gallate, anticancer drug, sunitinib
Issue Date: 22-Jan-2016
Citation: NUNNARPAS YONGVONGSOONTORN (2016-01-22). DESIGN OF POLYMERIC MICELLAR NANOCOMPLEXES COMPOSED OF GREEN TEA CATECHIN DERIVATIVES FOR CANCER THERAPY. ScholarBank@NUS Repository.
Abstract: (-)-Epigallocatechin-3-O-gallate (EGCG), a major ingredient of green tea, is recognized for its binding property and various beneficial effects, including anti-cancer effect. In this thesis, we have developed EGCG-based micellar nanocomplexes (MNCs) constructed by self-assembly of EGCG conjugated polyethylene glycol (PEG-EGCG) and small molecule chemotherapeutic, Sunitinib (SU). The SU-loaded PEG-EGCG MNCs (SU/PEG-EGCG MNCs) were obtained by the interaction between EGCG moieties and SU forming the core surrounded by PEG shell. The SU/PEG-EGCG MNCs efficiently suppressed tumor growth with higher tumor selectivity and longer blood half-life than intravenously injected free SU. This anti-cancer effect of SU/PEG-EGCG MNC was achieved by a much smaller amount of SU with no toxicity, as compared to conventional oral administration. The EGCG-based MNCs offered improved SU efficacy through highly specific tumor targeting, prolonged blood half-life and combinational effect between drug and carrier. This would overcome problems associated with conventional anticancer drugs, which usually have a narrow therapeutic window and severe side effects.
URI: http://scholarbank.nus.edu.sg/handle/10635/128795
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