Please use this identifier to cite or link to this item: https://doi.org/10.1080/10255842.2012.757598
Title: A computational model of amoeboid cell migration
Authors: Lim, F.Y.
Koon, Y.L. 
Chiam, K.-H.
Keywords: amoeboid protrusions
boundary integral method
cell migration
cellular blebs
Stokes flow
Issue Date: Oct-2013
Citation: Lim, F.Y., Koon, Y.L., Chiam, K.-H. (2013-10). A computational model of amoeboid cell migration. Computer Methods in Biomechanics and Biomedical Engineering 16 (10) : 1085-1095. ScholarBank@NUS Repository. https://doi.org/10.1080/10255842.2012.757598
Abstract: We present a two-dimensional computational model of amoeboid cell migration characterised by cell shape changes due to the formation and extension of protrusions known as blebs. Using this model, we numerically study the deformation of the cell membrane during blebbing, as well as the effects of obstacles, such as protein fibres in the extracellular matrix, on the motion of the blebbing cell. The model is established in the framework of Stokes flow. Cell membrane deformation is coupled to membrane tension, membrane bending, membrane-cortex adhesion and cortical activities via the intracellular and extracellular fluid field described by the Stokes equation. By assuming that actin monomers move at constant speed towards the membrane and polymerise when they approach the membrane, our model shows that the cell movement in unconfined space can be sustained. We also study how a migrating cell interacts with obstacles hydrodynamically, allowing us to model cell migration in confined environments and to investigate the effects of confinement on the cell migration speed. Our model can be used to further study how tumour cells move through the extracellular matrix during cancer metastasis. © 2013 © 2013 Taylor & Francis.
Source Title: Computer Methods in Biomechanics and Biomedical Engineering
URI: http://scholarbank.nus.edu.sg/handle/10635/128508
ISSN: 10255842
DOI: 10.1080/10255842.2012.757598
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

14
checked on Jun 15, 2018

WEB OF SCIENCETM
Citations

12
checked on May 21, 2018

Page view(s)

12
checked on Mar 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.