Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/128401
Title: METHODS FOR HIGH-PRECISION AND MINIMALLY INVASIVE MICRO-ELECTRODE INSERTION IN DEEP BRAIN STIMULATION
Authors: LI ZHE
Keywords: Deep brain stimulation, stereotactic operation, rotational microelectrode insertion, burr hole perforation, ultrasonic vibration, micro-hole forming
Issue Date: 26-May-2016
Citation: LI ZHE (2016-05-26). METHODS FOR HIGH-PRECISION AND MINIMALLY INVASIVE MICRO-ELECTRODE INSERTION IN DEEP BRAIN STIMULATION. ScholarBank@NUS Repository.
Abstract: Deep brain stimulation (DBS) is an established treatment for refractory neurodegenerative/neuropsychiatric disorders. However, DBS is lowly accepted because of the invasive operation and unsatisfactory stimulation efficacy. Invasive operations such as insertion of a thick electrode into brain and large burr hole opening on skull cause serious tissue damage; low targeting accuracy of electrode implantation causes unsatisfactory stimulation efficacy. The aim of this thesis is to develop a high-precision and minimally invasive electrode insertion operation. For this aim, two novel techniques for deflection-free microelectrode insertion and micro-hole forming on skull have been developed. A numerically controlled insertion system was constructed based on these techniques. Moreover, a pioneering microelectrode insertion operation has been developed. Compared with conventional operations, this operation is less invasive and has higher targeting accuracy. Adoption of this operation can help transform DBS into a safer treatment of higher efficacy, which will make DBS better accepted by patients.
URI: http://scholarbank.nus.edu.sg/handle/10635/128401
Appears in Collections:Ph.D Theses (Open)

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