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https://doi.org/10.1016/j.jgar.2013.11.003
Title: | Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010-2013 | Authors: | Teo, J.W.P. Tan, P. La, M.-V. Krishnan, P. Tee, N. Koh, T.H. Deepak, R.N. Tan, T.Y. Jureen, R. Lin, R.T.P. |
Keywords: | Antibiotic resistance Carbapenemase Clonality Plasmid |
Issue Date: | 2014 | Citation: | Teo, J.W.P., Tan, P., La, M.-V., Krishnan, P., Tee, N., Koh, T.H., Deepak, R.N., Tan, T.Y., Jureen, R., Lin, R.T.P. (2014). Surveillance trends of carbapenem-resistant Enterobacteriaceae from Singapore, 2010-2013. Journal of Global Antimicrobial Resistance 2 (2) : 99-102. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jgar.2013.11.003 | Abstract: | Trends in carbapenem-resistant Enterobacteriaceae (CRE) collected from hospitals nationwide in Singapore over 3 years are presented. Hospital isolates with imipenem or meropenem minimum inhibitory concentrations (MICs) of >1 mg/L were sent to the National Public Health Laboratory for further investigation. A total of 400 CRE were submitted, 227 (56.8%) of which carried a carbapenemase gene. blaNDM was the most common (130/400; 32.5%), followed by blaOXA-48-like (blaOXA-48, -181, -232) (55/400; 13.8%). Interestingly, four isolates bearing dual carbapenemase genes were also detected. KPC- and OXA-48-like-producing Klebsiella pneumoniae were fingerprinted by DiversiLab® rep-PCR. Locally, KPC producers do not appear to have clonal dissemination. In contrast, OXA-48-like producers were found to have a greater degree of clustering than KPC producers. © 2013 International Society for Chemotherapy of Infection and Cancer. | Source Title: | Journal of Global Antimicrobial Resistance | URI: | http://scholarbank.nus.edu.sg/handle/10635/127030 | ISSN: | 22137173 | DOI: | 10.1016/j.jgar.2013.11.003 |
Appears in Collections: | Staff Publications |
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