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|Title:||The role of the T follicular helper cells in allergic disease|
follicular helper T cells
|Source:||Kemeny, D. (2012-09). The role of the T follicular helper cells in allergic disease. Cellular and Molecular Immunology 9 (5) : 386-389. ScholarBank@NUS Repository. https://doi.org/10.1038/cmi.2012.31|
|Abstract:||T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 (Th2) effector cells. © 2012 CSI and USTC.|
|Source Title:||Cellular and Molecular Immunology|
|Appears in Collections:||Staff Publications|
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