Please use this identifier to cite or link to this item: https://doi.org/10.1038/cmi.2012.31
Title: The role of the T follicular helper cells in allergic disease
Authors: Kemeny, D. 
Keywords: allergy
asthma
follicular helper T cells
IgE
Issue Date: Sep-2012
Source: Kemeny, D. (2012-09). The role of the T follicular helper cells in allergic disease. Cellular and Molecular Immunology 9 (5) : 386-389. ScholarBank@NUS Repository. https://doi.org/10.1038/cmi.2012.31
Abstract: T follicular helper (Tfh) cells were discovered just over a decade ago as germinal centre T cells that help B cells make antibodies. Included in this role is affinity maturation and isotype switching. It is here that their functions become less clear. Tfh cells principally produce IL-21 which inhibits class switching to IgE. Recent studies have questioned whether the germinal centre is the main site of IgE class switching or IgE affinity maturation. In this review, I will examine the evidence that these cells are responsible for regulating IgE class switching and the relationship between Tfh cells and T helper 2 (Th2) effector cells. © 2012 CSI and USTC.
Source Title: Cellular and Molecular Immunology
URI: http://scholarbank.nus.edu.sg/handle/10635/126778
ISSN: 16727681
DOI: 10.1038/cmi.2012.31
Appears in Collections:Staff Publications

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