Please use this identifier to cite or link to this item: https://doi.org/10.1136/jnnp-2013-305397
Title: Pharyngeal-cervical-brachial variant of Guillain-Barré syndrome
Authors: Wakerley, B.R.
Yuki, N. 
Issue Date: Mar-2014
Citation: Wakerley, B.R., Yuki, N. (2014-03). Pharyngeal-cervical-brachial variant of Guillain-Barré syndrome. Journal of Neurology, Neurosurgery and Psychiatry 85 (3) : 339-344. ScholarBank@NUS Repository. https://doi.org/10.1136/jnnp-2013-305397
Abstract: The pharyngeal-cervical-brachial (PCB) variant of Guillain-Barré syndrome is defined by rapidly progressive oropharyngeal and cervicobrachial weakness associated with areflexia in the upper limbs. Serial nerve conduction studies suggest that PCB represents a localised subtype of Guillain-Barré syndrome characterised by axonal rather than demyelinating neuropathy. Many neurologists are unfamiliar with PCB, which is often misdiagnosed as brainstem stroke, myasthenia gravis or botulism. The presence of additional ophthalmoplegia and ataxia indicates overlap with Fisher syndrome. Half of patients with PCB carry IgG anti-GT1a antibodies which often cross-react with GQ1b, whereas most patients with Fisher syndrome carry IgG anti-GQ1b antibodies which always cross-react with GT1a. Significant overlap between the clinical and serological profiles of these patients supports the view that PCB and Fisher syndrome form a continuous spectrum. In this review, we highlight the clinical features of PCB and outline new diagnostic criteria.
Source Title: Journal of Neurology, Neurosurgery and Psychiatry
URI: http://scholarbank.nus.edu.sg/handle/10635/126775
ISSN: 00223050
DOI: 10.1136/jnnp-2013-305397
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