Please use this identifier to cite or link to this item:
|Title:||Brd4 and HEXIM1: Multiple roles in P-TEFb regulation and cancer|
|Citation:||Chen, R., Yik, J.H.N., Lew, Q.J., Chao, S.-H. (2014). Brd4 and HEXIM1: Multiple roles in P-TEFb regulation and cancer. BioMed Research International 2014 : -. ScholarBank@NUS Repository. https://doi.org/10.1155/2014/232870|
|Abstract:||Bromodomain-containing protein 4 (Brd4) and hexamethylene bisacetamide (HMBA) inducible protein 1 (HEXIM1) are two opposing regulators of the positive transcription elongation factor b (P-TEFb), which is the master modulator of RNA polymerase II during transcriptional elongation. While Brd4 recruits P-TEFb to promoter-proximal chromatins to activate transcription, HEXIM1 sequesters P-TEFb into an inactive complex containing the 7SK small nuclear RNA. Besides regulating P-TEFb's transcriptional activity, recent evidence demonstrates that both Brd4 and HEXIM1 also play novel roles in cell cycle progression and tumorigenesis. Here we will discuss the current knowledge on Brd4 and HEXIM1 and their implication as novel therapeutic options against cancer. © 2014 Ruichuan Chen et al.|
|Source Title:||BioMed Research International|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 13, 2018
WEB OF SCIENCETM
checked on Oct 30, 2018
checked on Nov 2, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.