Please use this identifier to cite or link to this item:
|Title:||The DNA damage response induces antigen presenting cell-like functions in fibroblasts|
|Citation:||Tang, M.L.F., Khan, M.K.N., Croxford, J.L., Tan, K.W., Angeli, V., Gasser, S. (2014). The DNA damage response induces antigen presenting cell-like functions in fibroblasts. European Journal of Immunology 44 (4) : 1108-1118. ScholarBank@NUS Repository. https://doi.org/10.1002/eji.201343781|
|Abstract:||The DNA damage response (DDR) alerts the immune system to the danger posed by DNA damage through the induction of damage-associated molecular pattern molecules, chemokines, and ligands for activating immune receptors such as lymphocyte function-associated antigen 1 (LFA-1), NKG2D, and DNAX accessory molecule 1 (DNAM-1). Here we provide evidence that OVA257-264-pulsed fibroblasts gain the ability to activate naïve OT-I CD8+ T cells in response to DNA damage. The ability of fibroblasts to activate OT-I CD8+ T cells depended on the upregulation of ICAM-1 on fibroblasts and DNAM-1 expression of CD8+ T cells. OVA257-264-pulsed fibroblasts were able to induce a protective T-cell response against B16-OVA cells in a DDR-dependent manner. Hence, the DDR may alert the immune system to the presence of potentially dangerous cells by upregulating the expression of ligands that can induce the activation of innate and adaptive immune cells. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||European Journal of Immunology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 21, 2018
WEB OF SCIENCETM
checked on May 9, 2018
checked on Jun 7, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.