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Title: The DNA damage response induces antigen presenting cell-like functions in fibroblasts
Authors: Tang, M.L.F.
Khan, M.K.N. 
Croxford, J.L. 
Tan, K.W. 
Angeli, V. 
Gasser, S. 
Keywords: Adaptive immunity
Antigen-presenting cell
DNA damage
Issue Date: 2014
Source: Tang, M.L.F., Khan, M.K.N., Croxford, J.L., Tan, K.W., Angeli, V., Gasser, S. (2014). The DNA damage response induces antigen presenting cell-like functions in fibroblasts. European Journal of Immunology 44 (4) : 1108-1118. ScholarBank@NUS Repository.
Abstract: The DNA damage response (DDR) alerts the immune system to the danger posed by DNA damage through the induction of damage-associated molecular pattern molecules, chemokines, and ligands for activating immune receptors such as lymphocyte function-associated antigen 1 (LFA-1), NKG2D, and DNAX accessory molecule 1 (DNAM-1). Here we provide evidence that OVA257-264-pulsed fibroblasts gain the ability to activate naïve OT-I CD8+ T cells in response to DNA damage. The ability of fibroblasts to activate OT-I CD8+ T cells depended on the upregulation of ICAM-1 on fibroblasts and DNAM-1 expression of CD8+ T cells. OVA257-264-pulsed fibroblasts were able to induce a protective T-cell response against B16-OVA cells in a DDR-dependent manner. Hence, the DDR may alert the immune system to the presence of potentially dangerous cells by upregulating the expression of ligands that can induce the activation of innate and adaptive immune cells. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: European Journal of Immunology
ISSN: 15214141
DOI: 10.1002/eji.201343781
Appears in Collections:Staff Publications

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