Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/126729
Title: In vitro drug interactions of gallates with antibiotics in Staphylococcus Aureus
Authors: Soe, W.M.
Lin, R.T.P. 
Lim, C.S.
Sakharkar, K.R.
Sakharkar, M.K.
Keywords: Antibiotics
Drug
MRSA
Resistance
Therapeutic intervention
Issue Date: 1-Jan-2010
Abstract: The antimicrobial activities of tetracycline, mupirocin, and fusidic acid are tested in combination with Epicatechin Gallate (ECG), and Ethyl Gallate (EG) using 2 Methicillin resistant (MRSA) and 2 Methicillin sensitive (MSSA) strains of Staphylococcus aureus. Sub-inhibitory concentration of EG at 256mg l -1 is found to be synergistic when used in combination with tetracycline, mupirocin, and fusidic acid; and a sub-inhibitory concentration of ECG at 32 mg l-1 is found to be synergistic with tetracycline in all the four Staphylococcus aureus strains tested. The synergistic combinations reduce the MICs of all the above three antibiotics by 4 fold. Combining ECG at 32mg l-1 with mupirocin, reduces the MIC of mupirocin by four fold in MSSA C1 strain. 74% of the combinations show consistent results in both time-kill assay and checkerboard method. The identified combinations may lead towards novel therapeutic interventions for treating MRSA infections.
Source Title: Frontiers in Bioscience - Elite
URI: http://scholarbank.nus.edu.sg/handle/10635/126729
ISSN: 19450494
Appears in Collections:Staff Publications

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