Please use this identifier to cite or link to this item:
|Title:||IgG1 + ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells|
|Citation:||Dougan, S.K., Ogata, S., Hu, C.-C.A., Grotenbreg, G.M., Guillen, E., Jaenisch, R., Ploegh, H.L. (2012-08-21). IgG1 + ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proceedings of the National Academy of Sciences of the United States of America 109 (34) : 13739-13744. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.1210273109|
|Abstract:||We used somatic cell nuclear transfer (SCNT) to generate a mouse from the nucleus of an IgG1 + ovalbumin-specific B cell. The resulting OBI mice show generally normal B-cell development, with elevated percentages of marginal zone B cells and a reduction in B-1 B cells. Whereas OBI RAG1 -/- mice have exclusively IgG1 anti-ovalbumin in their serum, OBI mice show elevated levels of anti-ovalbumin of nearly all isotypes 3′ of the γ1 constant region in the IgH locus, indicating that class switch recombination (CSR) occurs in the absence of immunization with ovalbumin. This CSR is associated with the presence of IgM +IgG1 + double producer B cells that represent|
|Source Title:||Proceedings of the National Academy of Sciences of the United States of America|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 21, 2019
WEB OF SCIENCETM
checked on Jan 2, 2019
checked on Jan 18, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.