Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0097523
Title: Enterococcus faecalis from healthy infants modulates inflammation through MAPK signaling pathways
Authors: Wang, S.
Hibberd, M.L.
Pettersson, S.
Lee, Y.K. 
Issue Date: 15-May-2014
Citation: Wang, S., Hibberd, M.L., Pettersson, S., Lee, Y.K. (2014-05-15). Enterococcus faecalis from healthy infants modulates inflammation through MAPK signaling pathways. PLoS ONE 9 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0097523
Abstract: Colonizing commensal bacteria after birth are required for the proper development of the gastrointestinal tract. It is believed that bacterial colonization pattern in neonatal gut affects gut barrier function and immune system maturation. Studies on the development of faecal microbiota in infants showed that the neonatal gut was first colonized with enterococci followed by other microbiota such as Bifidobacterium. Other studies showed that babies who developed allergy were less often colonized with Enterococcus during the first month of life as compared to healthy infants. Many studies have been conducted to elucidate how bifidobacteria or lactobacilli, some of which are considered probiotic, regulate infant gut immunity. However, fewer studies have been focused on enterococi. In our study, we demonstrate that E. faecalis, isolated from healthy newborns, suppress inflammatory responses activated in vivo and in vitro. We found E. faecalis attenuates proinflammatory cytokine secretions, especially IL-8, through JNK and p38 signaling pathways. This finding shed light on how the first colonizer, E.faecalis, regulates inflammatory responses in the host. © 2014 Wang et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/126724
ISSN: 19326203
DOI: 10.1371/journal.pone.0097523
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