Please use this identifier to cite or link to this item: https://doi.org/10.1083/jcb.201003095
Title: Mad2 inhibits the mitotic kinesin MKlp2
Authors: Lee, S.H. 
McCormick, F.
Saya, H.
Issue Date: 13-Dec-2010
Citation: Lee, S.H., McCormick, F., Saya, H. (2010-12-13). Mad2 inhibits the mitotic kinesin MKlp2. Journal of Cell Biology 191 (6) : 1069-1077. ScholarBank@NUS Repository. https://doi.org/10.1083/jcb.201003095
Abstract: We identified the mitotic kinesin-like protein 2 (MKlp2), a kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis, as a target of the mitotic checkpoint protein Mad2. MKlp2 possesses a consensus Mad2-binding motif required for Mad2 binding. Mad2 prevents MKlp2 from loading onto the mitotic spindle, a prerequisite step for its function as a mitotic kinesin. Furthermore, Mad2 inhibits the ability of MKlp2 to relocate the CPC from centromeres, an essential step to promote cytokinesis. An MKlp2 mutant that is refractory to Mad2-mediated inhibition prematurely translocates to the mitotic spindle and mislocalizes the CPC component Aurora B from the midbody of dividing cells. This correlates with an increased incidence of cytokinesis failure. Together, these findings reveal that MKlp2 is a novel mitotic target of Mad2 necessary for proper mitotic progression and cytokinesis. © 2010 Lee et al.
Source Title: Journal of Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/126512
ISSN: 00219525
DOI: 10.1083/jcb.201003095
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

22
checked on Dec 4, 2018

WEB OF SCIENCETM
Citations

21
checked on Dec 4, 2018

Page view(s)

13
checked on Nov 23, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.