Please use this identifier to cite or link to this item:
|Title:||Mad2 inhibits the mitotic kinesin MKlp2|
|Authors:||Lee, S.H. |
|Citation:||Lee, S.H., McCormick, F., Saya, H. (2010-12-13). Mad2 inhibits the mitotic kinesin MKlp2. Journal of Cell Biology 191 (6) : 1069-1077. ScholarBank@NUS Repository. https://doi.org/10.1083/jcb.201003095|
|Abstract:||We identified the mitotic kinesin-like protein 2 (MKlp2), a kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis, as a target of the mitotic checkpoint protein Mad2. MKlp2 possesses a consensus Mad2-binding motif required for Mad2 binding. Mad2 prevents MKlp2 from loading onto the mitotic spindle, a prerequisite step for its function as a mitotic kinesin. Furthermore, Mad2 inhibits the ability of MKlp2 to relocate the CPC from centromeres, an essential step to promote cytokinesis. An MKlp2 mutant that is refractory to Mad2-mediated inhibition prematurely translocates to the mitotic spindle and mislocalizes the CPC component Aurora B from the midbody of dividing cells. This correlates with an increased incidence of cytokinesis failure. Together, these findings reveal that MKlp2 is a novel mitotic target of Mad2 necessary for proper mitotic progression and cytokinesis. © 2010 Lee et al.|
|Source Title:||Journal of Cell Biology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 19, 2019
WEB OF SCIENCETM
checked on Mar 4, 2019
checked on Nov 23, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.