Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms1432
Title: Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China
Authors: Lessler, J.
Cummings, D.A.T.
Read, J.M.
Wang, S.
Zhu, H.
Smith, G.J.D. 
Guan, Y.
Jiang, C.Q.
Riley, S.
Issue Date: 2011
Citation: Lessler, J., Cummings, D.A.T., Read, J.M., Wang, S., Zhu, H., Smith, G.J.D., Guan, Y., Jiang, C.Q., Riley, S. (2011). Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China. Nature Communications 2 (1) : -. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms1432
Abstract: Variation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show that significant differences in immunity to influenza A viruses among communities in China are not explained by differences in population demographics. We randomly selected households from five randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against five recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, levelling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain. © 2011 Macmillan Publishers Limited. All rights reserved.
Source Title: Nature Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/126510
ISSN: 20411723
DOI: 10.1038/ncomms1432
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Dec 14, 2018

WEB OF SCIENCETM
Citations

19
checked on Dec 5, 2018

Page view(s)

24
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.