Please use this identifier to cite or link to this item:
|Title:||Hemophagocytic lymphohistiocytosis with isolated central nervous system reactivation and optic nerve involvement|
|Keywords:||central nervous system|
|Citation:||Chong, K.W., Lee, J.H., Choong, C.T., Med, M., Chan, D.W.S., Fortier, M.V., Chan, M.Y. (2012-10). Hemophagocytic lymphohistiocytosis with isolated central nervous system reactivation and optic nerve involvement. Journal of Child Neurology 27 (10) : 1336-1339. ScholarBank@NUS Repository. https://doi.org/10.1177/0883073811435237|
|Abstract:||Hemophagocytic lymphohistiocytosis is a rare childhood disorder characterized by uncontrolled proliferation of benign lymphocytes and histiocytes in multiple organs. Neurological presentations of central nervous system involvement are highly variable. The authors present a case of familial hemophagocytic lymphohistiocytosis in an 8-month-old girl with isolated central nervous system reactivation and optic nerve involvement. She presented with fever and hepatosplenomegaly at 2 months of age. Genetic studies confirmed familial hemophagocytic lymphohistiocytosis. There were no clinical features of central nervous system involvement at presentation. While on maintenance chemotherapy awaiting bone marrow transplant, she presented with new-onset seizures. Magnetic resonance imaging of the brain revealed extensive areas of abnormal signal and a thickened and enhancing left optic nerve. Ocular manifestations of hemophagocytic lymphohistiocytosis have rarely been described. To the authors' knowledge, this is the first case report of magnetic resonance imaging findings of optic nerve involvement in a child with hemophagocytic lymphohistiocytosis. © The Author(s) 2012.|
|Source Title:||Journal of Child Neurology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 23, 2018
WEB OF SCIENCETM
checked on May 29, 2018
checked on May 24, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.