Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.resuscitation.2012.02.005
Title: A randomised, double-blind, multi-centre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the Emergency Department
Authors: Ong, M.E.H. 
Tiah, L.
Leong, B.S.-H.
Tan, E.C.C.
Ong, V.Y.K.
Tan, E.A.T.
Poh, B.Y.
Pek, P.P.
Chen, Y.
Keywords: Cardiac
Cardiopulmonary resuscitation
Cardiovascular agents
Death
Epinephrine
Sudden
Vasoconstrictor agents
Vasopressins
Issue Date: Aug-2012
Citation: Ong, M.E.H., Tiah, L., Leong, B.S.-H., Tan, E.C.C., Ong, V.Y.K., Tan, E.A.T., Poh, B.Y., Pek, P.P., Chen, Y. (2012-08). A randomised, double-blind, multi-centre trial comparing vasopressin and adrenaline in patients with cardiac arrest presenting to or in the Emergency Department. Resuscitation 83 (8) : 953-960. ScholarBank@NUS Repository. https://doi.org/10.1016/j.resuscitation.2012.02.005
Abstract: Objective: To compare vasopressin and adrenaline in the treatment of patients with cardiac arrest presenting to or in the Emergency Department (ED). Design: A randomised, double-blind, multi-centre, parallel-design clinical trial in four adult hospitals. Method: Eligible cardiac arrest patients (confirmed by the absence of pulse, unresponsiveness and apnea) aged >16 (aged > 21 for one hospital) were randomly assigned to intravenous adrenaline (1. mg) or vasopressin (40. IU) at ED. Patients with traumatic cardiac arrest or contraindication for cardiopulmonary resuscitation (CPR) were excluded. Patients received additional open label doses of adrenaline as per current guidelines. Primary outcome was survival to hospital discharge (defined as participant discharged alive or survival to 30 days post-arrest). Main results: The study recruited 727 participants (adrenaline = 353; vasopressin = 374). Baseline characteristics of the two groups were comparable. Eight participants (2.3%) from adrenaline and 11 (2.9%) from vasopressin group survived to hospital discharge with no significant difference between groups (p= 0.27, RR = 1.72, 95% CI = 0.65-4.51). After adjustment for race, medical history, bystander CPR and prior adrenaline given, more participants survived to hospital admission with vasopressin (22.2%) than with adrenaline (16.7%) (p= 0.05, RR = 1.43, 95% CI = 1.02-2.04). Sub-group analysis suggested improved outcomes for vasopressin in participants with prolonged arrest times. Conclusions: Combination of vasopressin and adrenaline did not improve long term survival but seemed to improve survival to admission in patients with prolonged cardiac arrest. Further studies on the effect of vasopressin combined with therapeutic hypothermia on patients with prolonged cardiac arrest are needed. © 2012 Elsevier Ireland Ltd.
Source Title: Resuscitation
URI: http://scholarbank.nus.edu.sg/handle/10635/126462
ISSN: 03009572
DOI: 10.1016/j.resuscitation.2012.02.005
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