Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.humpath.2012.11.019
Title: Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma
Authors: Petersson, F. 
Grossmann, P.
Hora, M.
Sperga, M.
Montiel, D.P.
Martinek, P.
Gutierrez, M.E.C.
Bulimbasic, S.
Michal, M.
Branzovsky, J.
Hes, O.
Keywords: Clear cell papillary renal cell carcinoma
Clear renal cell carcinoma
Immunohistochemistry
Molecular genetics
Renal angiomyomatous tumor
Issue Date: Jul-2013
Source: Petersson, F., Grossmann, P., Hora, M., Sperga, M., Montiel, D.P., Martinek, P., Gutierrez, M.E.C., Bulimbasic, S., Michal, M., Branzovsky, J., Hes, O. (2013-07). Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma. Human Pathology 44 (7) : 1412-1420. ScholarBank@NUS Repository. https://doi.org/10.1016/j.humpath.2012.11.019
Abstract: We present a cohort of 8 renal carcinomas that displayed a variable (5%-95% extent) light microscopic appearance of renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma (RAT/CCPRCC) without fulfilling the criteria for these tumors. All but 1 case predominantly (75%-95% extent) showed histopathologic features of conventional clear cell renal cell carcinoma. In 5 of 7 cases with mostly conventional clear renal cell carcinoma (CRCC) morphology, a diagnosis of CRCC was supported by the molecular genetic findings (presence of von Hippel-Lindau tumor suppressor [VHL] mutation and/or VHL promoter methylation and/or loss of heterozygosity [LOH] for 3p). Of the other 2 cases with predominantly characteristic CRCC morphology, 1 tumor did not reveal any VHL mutation, VHL promoter methylation, or LOH for 3p, and both chromosomes 7 and 17 were disomic, whereas the other tumor displayed polysomy for chromosomes 7 and 17 and no VHL mutation, VHL promoter methylation, or LOH for 3p. One tumor was composed primarily (95%) of distinctly RAT/CCPRCC-like morphology, and this tumor harbored a VHL mutation and displayed polysomy for chromosomes 7 and 17. Of the 5 cases with both histomorphologic features and molecular genetic findings of CRCC, we detected significant immunoreactivity for α-methylacyl-CoA racemase in 2 cases and strong diffuse immunopositivity for cytokeratin 7 in 3 cases. Despite the combination of positivity for α-methylacyl-CoA racemase and cytokeratin 7 in 2 cases, there was nothing to suggest of the possibility of a conventional papillary renal cell carcinoma with a predominance of clear cells. © 2013 Elsevier Inc.
Source Title: Human Pathology
URI: http://scholarbank.nus.edu.sg/handle/10635/125632
ISSN: 00468177
DOI: 10.1016/j.humpath.2012.11.019
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