Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00428-013-1457-6
Title: Chromophobe renal cell carcinoma-chromosomal aberration variability and its relation to Paner grading system: An array CGH and FISH analysis of 37 cases
Authors: Sperga, M.
Martinek, P.
Vanecek, T.
Grossmann, P.
Bauleth, K.
Perez-Montiel, D.
Alvarado-Cabrero, I.
Nevidovska, K.
Lietuvietis, V.
Hora, M.
Michal, M.
Petersson, F. 
Kuroda, N.
Suster, S.
Branzovsky, J.
Hes, O.
Keywords: Array CGH
Chromophobe renal cell carcinoma
Chromosomal numerical aberrations
FISH
Paner grade
Issue Date: Oct-2013
Citation: Sperga, M., Martinek, P., Vanecek, T., Grossmann, P., Bauleth, K., Perez-Montiel, D., Alvarado-Cabrero, I., Nevidovska, K., Lietuvietis, V., Hora, M., Michal, M., Petersson, F., Kuroda, N., Suster, S., Branzovsky, J., Hes, O. (2013-10). Chromophobe renal cell carcinoma-chromosomal aberration variability and its relation to Paner grading system: An array CGH and FISH analysis of 37 cases. Virchows Archiv 463 (4) : 563-573. ScholarBank@NUS Repository. https://doi.org/10.1007/s00428-013-1457-6
Abstract: Genetically, chromophobe renal cell carcinoma (ChRCC) is characterized by multiple chromosomal changes, especially losses. The most common losses include chromosomes 1, 2, 6, 10, 13, 17, and 21. The Fuhrman grading system lacks prognostic relevance for ChRCC, and recently, a new grading system for ChRCC was proposed by Paner. The objective of this study was to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of ChRCCs and relate these findings to the Paner grading system (PGS). A large cohort of ChRCC was reviewed and graded according to the PGS. All the cases were reevaluated and separated into groups according to their PGS. The final study set was 37 patients. ChRCCs were divided into PG 1-3, sarcomatoid, and aggressive groups. "Aggressive ChRCCs" were designated cases with known metastatic activity, local recurrence, aggressive growth to the adjacent organs, or invasive growth into the renal sinus (with/without angioinvasion). Sarcomatoid tumors were divided into their epithelial and sarcomatoid component (further molecular genetic analyses were performed separately). Array comparative genome hybridization and/or fluorescence in situ hybridization analysis was applied to 42 samples from the 37 cases. Multiple losses, as well as gains, were detected in different chromosomes. Regardless of the PGS groups, the most frequently detected losses involved chromosomes 1 (27/37), 2 (26/37), 6 (23/37), 10 (26/37), 13 (19/37), and 17 (24/37). Loss of chromosome 21 was found in 12/37 cases. The most frequently detected gains were found on chromosomes 4 (22/37), 7 (24/37), 15 (20/37), 19 (22/37), and 20 (21/37). Cluster analysis showed that there is no relation between PGS and particular pattern of chromosomal changes (losses or gains) in ChRCCs. Conclusions are as follows: (1) ChRCCs showed a significantly broader spectrum of chromosomal aberrations than previously recognized. While previously published chromosomal losses were found in our cohort, gains of multiple chromosomes were also identified in a high percentage. The most frequently detected gains involved chromosomes 4, 7, 15, 19, and 20. (2) There is no relation between chromosomal numerical changes and Paner grading system. © 2013 Springer-Verlag Berlin Heidelberg.
Source Title: Virchows Archiv
URI: http://scholarbank.nus.edu.sg/handle/10635/125623
ISSN: 09456317
DOI: 10.1007/s00428-013-1457-6
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

16
checked on Jul 18, 2018

WEB OF SCIENCETM
Citations

14
checked on Jun 4, 2018

Page view(s)

63
checked on Jul 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.