Please use this identifier to cite or link to this item: https://doi.org/10.1111/bjh.12042
Title: The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report
Authors: Patel, J.L.
Smith, L.M.
Anderson, J.
Abromowitch, M.
Campana, D. 
Jacobsen, J.
Lones, M.A.
Gross, T.G.
Cairo, M.S.
Perkins, S.L.
Keywords: Early T-cell precursor
Immunophenotypic analysis
Paediatric lymphoma
T-cell antigens
T-lymphoblastic lymphoma
Issue Date: Nov-2012
Citation: Patel, J.L., Smith, L.M., Anderson, J., Abromowitch, M., Campana, D., Jacobsen, J., Lones, M.A., Gross, T.G., Cairo, M.S., Perkins, S.L. (2012-11). The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report. British Journal of Haematology 159 (4) : 454-461. ScholarBank@NUS Repository. https://doi.org/10.1111/bjh.12042
Abstract: T-lymphoblastic leukaemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms derived from immature lymphoid cells of T-cell lineage. These neoplasms are biologically similar, but significant differences may exist between the two given their clinical differences. Although ample data regarding the immunophenotypic characterization T-ALL are available, there is a paucity of such data in children and adolescents with T-LBL. We used flow cytometry and/or immunohistochemistry to characterize the immunophenotypic profile of 180 children and adolescents with newly diagnosed T-LBL enrolled in the Children's Oncology Group 5971 study. Multiple T-cell, B-cell, myeloid, and other markers were evaluated. We identified diagnostically useful immunophenotypic features of T-LBL as well as distinct immunophenotypic subgroups, although none of these was statistically related to event-free or overall survival in this retrospective analysis. Further studies of biologically and immunophenotypically distinct subgroups of T-LBL, such as the early T-cell precursor phenotype, are warranted. © 2012 Blackwell Publishing Ltd.
Source Title: British Journal of Haematology
URI: http://scholarbank.nus.edu.sg/handle/10635/125616
ISSN: 00071048
DOI: 10.1111/bjh.12042
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

28
checked on Dec 12, 2018

WEB OF SCIENCETM
Citations

23
checked on Dec 12, 2018

Page view(s)

23
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.