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Title: The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report
Authors: Patel, J.L.
Smith, L.M.
Anderson, J.
Abromowitch, M.
Campana, D. 
Jacobsen, J.
Lones, M.A.
Gross, T.G.
Cairo, M.S.
Perkins, S.L.
Keywords: Early T-cell precursor
Immunophenotypic analysis
Paediatric lymphoma
T-cell antigens
T-lymphoblastic lymphoma
Issue Date: Nov-2012
Source: Patel, J.L., Smith, L.M., Anderson, J., Abromowitch, M., Campana, D., Jacobsen, J., Lones, M.A., Gross, T.G., Cairo, M.S., Perkins, S.L. (2012-11). The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report. British Journal of Haematology 159 (4) : 454-461. ScholarBank@NUS Repository.
Abstract: T-lymphoblastic leukaemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms derived from immature lymphoid cells of T-cell lineage. These neoplasms are biologically similar, but significant differences may exist between the two given their clinical differences. Although ample data regarding the immunophenotypic characterization T-ALL are available, there is a paucity of such data in children and adolescents with T-LBL. We used flow cytometry and/or immunohistochemistry to characterize the immunophenotypic profile of 180 children and adolescents with newly diagnosed T-LBL enrolled in the Children's Oncology Group 5971 study. Multiple T-cell, B-cell, myeloid, and other markers were evaluated. We identified diagnostically useful immunophenotypic features of T-LBL as well as distinct immunophenotypic subgroups, although none of these was statistically related to event-free or overall survival in this retrospective analysis. Further studies of biologically and immunophenotypically distinct subgroups of T-LBL, such as the early T-cell precursor phenotype, are warranted. © 2012 Blackwell Publishing Ltd.
Source Title: British Journal of Haematology
ISSN: 00071048
DOI: 10.1111/bjh.12042
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