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|Title:||The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report|
|Keywords:||Early T-cell precursor|
|Citation:||Patel, J.L., Smith, L.M., Anderson, J., Abromowitch, M., Campana, D., Jacobsen, J., Lones, M.A., Gross, T.G., Cairo, M.S., Perkins, S.L. (2012-11). The immunophenotype of T-lymphoblastic lymphoma in children and adolescents: A children's oncology group report. British Journal of Haematology 159 (4) : 454-461. ScholarBank@NUS Repository. https://doi.org/10.1111/bjh.12042|
|Abstract:||T-lymphoblastic leukaemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms derived from immature lymphoid cells of T-cell lineage. These neoplasms are biologically similar, but significant differences may exist between the two given their clinical differences. Although ample data regarding the immunophenotypic characterization T-ALL are available, there is a paucity of such data in children and adolescents with T-LBL. We used flow cytometry and/or immunohistochemistry to characterize the immunophenotypic profile of 180 children and adolescents with newly diagnosed T-LBL enrolled in the Children's Oncology Group 5971 study. Multiple T-cell, B-cell, myeloid, and other markers were evaluated. We identified diagnostically useful immunophenotypic features of T-LBL as well as distinct immunophenotypic subgroups, although none of these was statistically related to event-free or overall survival in this retrospective analysis. Further studies of biologically and immunophenotypically distinct subgroups of T-LBL, such as the early T-cell precursor phenotype, are warranted. © 2012 Blackwell Publishing Ltd.|
|Source Title:||British Journal of Haematology|
|Appears in Collections:||Staff Publications|
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