Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.fob.2014.04.005
Title: Elucidating the host-pathogen interaction between human colorectal cells and invading Enterovirus 71 using transcriptomics profiling
Authors: Lui, Y.L.E.
Tan, T.L.
Timms, P.
Hafner, L.M.
Tan, K.H.
Tan, E.L. 
Keywords: Colorectal cells
Enterovirus 71
Hand foot and mouth disease
Microarray
MRNA profiling
Transcriptomics
Issue Date: 2014
Citation: Lui, Y.L.E., Tan, T.L., Timms, P., Hafner, L.M., Tan, K.H., Tan, E.L. (2014). Elucidating the host-pathogen interaction between human colorectal cells and invading Enterovirus 71 using transcriptomics profiling. FEBS Open Bio 4 : 426-431. ScholarBank@NUS Repository. https://doi.org/10.1016/j.fob.2014.04.005
Abstract: Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD) and has been shown to be associated with severe clinical manifestation. Currently, there is no antiviral therapeutic for the treatment of HFMD patients owing to a lack of understanding of EV71 pathogenesis. This study seeks to elucidate the transcriptomic changes that result from EV71 infection. Human whole genome microarray was employed to monitor changes in genomic profiles between infected and uninfected cells. The results reveal altered expression of human genes involved in critical pathways including the immune response and the stress response. Together, data from this study provide valuable insights into the host-pathogen interaction between human colorectal cells and EV71. © 2014 The Authors.
Source Title: FEBS Open Bio
URI: http://scholarbank.nus.edu.sg/handle/10635/125603
ISSN: 22115463
DOI: 10.1016/j.fob.2014.04.005
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