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|Title:||Role of efflux pump inhibitors on the antibiofilm efficacy of calcium hydroxide, chitosan nanoparticles, and light-activated disinfection|
|Authors:||Upadya, M. |
light activated disinfection
|Citation:||Upadya, M., Shrestha, A., Kishen, A. (2011-10). Role of efflux pump inhibitors on the antibiofilm efficacy of calcium hydroxide, chitosan nanoparticles, and light-activated disinfection. Journal of Endodontics 37 (10) : 1422-1426. ScholarBank@NUS Repository. https://doi.org/10.1016/j.joen.2011.06.017|
|Abstract:||Introduction: The purpose of this study was to evaluate the role of efflux pumps in altering the susceptibility of Enterococcus faecalis biofilms to calcium hydroxide (Ca(OH) 2), chitosan nanoparticles, and light-activated disinfection (LAD). Methods: E. faecalis as 4-day-old biofilms and biofilm-derived cells were tested with aqueous Ca(OH) 2 in concentrations of 25%, 50%, and 100%; chitosan nanoparticles in concentrations of 10 and 20 mg/mL (3, 12, and 24 hours); and methylene blue (MB) mediated LAD at an energy dose range of 2-40 J/cm 2. An efflux pump inhibitor (EPI) was incorporated into all 3 modalities of treatment. The antimicrobial activity was assessed by determining the colony-forming units. Results: E. faecalis biofilms, in contrast to the biofilm-derived cells, were found to persist even after 24-hour treatment with different concentrations of Ca(OH) 2 and chitosan nanoparticles. LAD at an energy dose of 40 J/cm 2 completely inactivated 4-day-old E. faecalis biofilms. The addition of EPI improved the antibiofilm efficacy of Ca(OH) 2 at lower concentrations (P|
|Source Title:||Journal of Endodontics|
|Appears in Collections:||Staff Publications|
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