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Title: Under pressure: The search for the essential mechanisms of hypertension
Authors: Coffman, T.M. 
Issue Date: Nov-2011
Source: Coffman, T.M. (2011-11). Under pressure: The search for the essential mechanisms of hypertension. Nature Medicine 17 (11) : 1402-1409. ScholarBank@NUS Repository.
Abstract: High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysiology of hypertension. I present a general overview of the field and, by necessity, use broad strokes to portray recent progress and place it in context. For this purpose, I use illustrative examples from the large number of important developments in hypertension research over the last five years. The intent of this review is to provide a sense of where the field is progressing, with an emphasis on work that sheds light on pathogenic mechanisms and that is therefore likely to inform new translational advances. © 2011 Nature America, Inc. All rights reserved.
Source Title: Nature Medicine
ISSN: 10788956
DOI: 10.1038/nm.2541
Appears in Collections:Staff Publications

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