Please use this identifier to cite or link to this item:
|Title:||Elements in the canine distemper virus M 3′ UTR contribute to control of replication efficiency and virulence|
|Authors:||Anderson, D.E. |
Von Messling, V.
|Source:||Anderson, D.E., Castan, A., Bisaillon, M., Von Messling, V. (2012-02-13). Elements in the canine distemper virus M 3′ UTR contribute to control of replication efficiency and virulence. PLoS ONE 7 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0031561|
|Abstract:||Canine distemper virus (CDV) is a negative-sense, single-stranded RNA virus within the genus Morbillivirus and the family Paramyxoviridae. The Morbillivirus genome is composed of six transcriptional units that are separated by untranslated regions (UTRs), which are relatively uniform in length, with the exception of the UTR between the matrix (M) and fusion (F) genes. This UTR is at least three times longer and in the case of CDV also highly variable. Exchange of the M-F region between different CDV strains did not affect virulence or disease phenotype, demonstrating that this region is functionally interchangeable. Viruses carrying the deletions in the M 3′ UTR replicated more efficiently, which correlated with a reduction of virulence, suggesting that overall length as well as specific sequence motifs distributed throughout the region contribute to virulence. © 2012 Anderson et al.|
|Source Title:||PLoS ONE|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 6, 2018
WEB OF SCIENCETM
checked on Jan 23, 2018
checked on Mar 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.