Please use this identifier to cite or link to this item:
|Title:||Myocardial contractile dysfunction associated with increased 3-month and 1-year mortality in hospitalized patients with heart failure and preserved ejection fraction|
|Citation:||Zhong, L., Ng, K.K.C., Sim, L.L., Allen, J.C., Lau, Y.H., Sim, D.K.L., Lee, R.K.K., Poh, K.K., Chua, T.S.J., Kassab, G.S., Kwok, B.W.K., Tan, R.S. (2013-10-03). Myocardial contractile dysfunction associated with increased 3-month and 1-year mortality in hospitalized patients with heart failure and preserved ejection fraction. International Journal of Cardiology 168 (3) : 1975-1983. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijcard.2012.12.084|
|Abstract:||Background There is a clinical need for a contractility index that reflects myocardial contractile dysfunction even when ejection fraction (EF) is preserved. We used novel relative load-independent global and regional contractility indices to compare left ventricular (LV) contractile function in three groups: heart failure (HF) with preserved ejection fraction (HFPEF), HF with reduced ejection fraction (HFREF) and normal subjects. Also, we determined the associations of these parameters with 3-month and 1-year mortality in HFPEF patients. Methods 199 HFPEF patients [median age (IQR): 75 (67-80) years] and 327 HFREF patients [69 (59-76) years] were recruited following hospitalization for HF; 22 normal control subjects [65 (54-71) years] were recruited for comparison. All patients underwent standard two-dimensional Doppler and tissue Doppler echocardiography to characterize LV dimension, structure, global and regional contractile function. Results The median (IQR) global LV contractility index, dσ*/dtmax was 4.30 s- 1 (3.51-4.57 s- 1) in normal subjects but reduced in HFPEF [2.57 (2.08-3.64)] and HFREF patients [1.77 (1.34-2.30)]. Similarly, median (IQR) regional LV contractility index was 99% (88-104%) in normal subjects and reduced in HFPEF [81% (66-96%)] and HFREF [56% (41-71%)] patients. Multi-variable logistic regression analysis on HFPEF identified sc-mFS < 76% as the most consistent predictor of both 3-month (OR = 7.15, p < 0.05) and 1-year (OR = 2.57, p < 0.05) mortality after adjusting for medical conditions and other echocardiographic measurements. Conclusion Patients with HFPEF exhibited decreased LV global and regional contractility. This population-based study demonstrated that depressed regional contractility index was associated with higher 3-month and 1-year mortality in HFPEF patients. © 2013 Elsevier Ireland Ltd. All rights reserved.|
|Source Title:||International Journal of Cardiology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 24, 2018
WEB OF SCIENCETM
checked on Sep 24, 2018
checked on Sep 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.