Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0079211
Title: Genetic association study between STK39 and CCDC62/HIP1R and Parkinson's disease
Authors: Li, N.-N.
Tan, E.-K. 
Chang, X.-L.
Mao, X.-Y.
Zhang, J.-H.
Zhao, D.-M.
Liao, Q.
Yu, W.-J.
Peng, R.
Issue Date: 27-Nov-2013
Citation: Li, N.-N., Tan, E.-K., Chang, X.-L., Mao, X.-Y., Zhang, J.-H., Zhao, D.-M., Liao, Q., Yu, W.-J., Peng, R. (2013-11-27). Genetic association study between STK39 and CCDC62/HIP1R and Parkinson's disease. PLoS ONE 8 (11) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0079211
Abstract: Background: The first large-scale meta-analysis of published genome-wide association studies (GWAS) in Parkinson's disease (PD) identified 5 new genetic loci (ACMSD, STK39, MCCC1/LAMP3 , SYT11, and CCDC62/HIP1R). Very recently, a largescale replication and heterogeneity study also reported that STK39 and CCDC62/HIP1R increased risk of PD in Asian and Caucasian populations. However, their roles still remain unclear in a Han Chinese population from mainland China. Methods: We examined genetic associations of STK39 rs2102808 and CCDC62/HIP1R rs12817488 with PD susceptibility in a Han Chinese population of 783 PD patients and 725 controls. We also performed further stratified analyses by the age of onset and accomplished in-depth clinical characteristics analyses between the different genotypes for each locus. Results: No significant differences were observed in the minor allele frequency (MAF) among cases and controls at the two loci (STK39 rs2102808: OR = 1.06, 95% CI = 0.91, 1.23, P = 0.467; CCDC62/HIP1R rs12817488: OR = 0.88, 95% CI = 0.76, 1.01, P = 0.072). Subgroup analyses by the age of onset also showed no significant differences among different subgroups of the two loci. In addition, minor allele carriers cannot be distinguished from non-carriers based on their clinical features at the two loci. Conclusions: We are unable to demonstrate the association between STK39 and CCDC62/HIP1R and PD susceptibility in a Han Chinese population from mainland China. Additional replication studies in other populations and functional studies are warranted to better validate the role of the two new loci in PD risk. © 2013 Li et al.
Source Title: PLoS ONE
URI: http://scholarbank.nus.edu.sg/handle/10635/124704
ISSN: 19326203
DOI: 10.1371/journal.pone.0079211
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