Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/124162
Title: EFFECTS OF H2S ON ORAL FLORA AND HOST INFLAMMATORY RESPONSE
Authors: OOI XI JIA
Keywords: H2S; periodontal disease; glutathione; oxidative stress; oral streptococci; periodontal fibroblast
Issue Date: 19-Jan-2016
Citation: OOI XI JIA (2016-01-19). EFFECTS OF H2S ON ORAL FLORA AND HOST INFLAMMATORY RESPONSE. ScholarBank@NUS Repository.
Abstract: Periodontitis is a bacteria induced inflammatory disease resulting in the destruction of the periodontium. Oral streptococci predominate during periodontal health while Gram negative anaerobes such as Fusobacterium nucleatum increase in amounts in disease. F. nucleatum and other periodontitis associated bacteria produce H2S in abundance. However, the potential effects of H2S on periodontal health associated oral flora, and inflammatory response of cells in the periodontium have not been well studied. We found that H2S protected F. nucleatum from oxidative stress, and elicited differential microbicidal effects on different oral streptococci species, attributed to distinct levels of intracellular glutathione. In primary human periodontal fibroblasts, H2S elicited disparate inflammatory response where it induces cytokine production in the absence of toll like receptor (TLR) activation but inhibited cytokine production in the presence of TLR-activation. Collectively these data provide new insights of the multifaceted roles of H2S as a potential bacterial virulence factor in periodontitis.
URI: http://scholarbank.nus.edu.sg/handle/10635/124162
Appears in Collections:Ph.D Theses (Open)

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