Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/124085
Title: DNA DAMAGE RESPONSES IN AEROALLERGEN-INDUCED ASTHMA
Authors: CHAN TZE KHEE
Keywords: Asthma, House dust mite, DNA damage, DNA repair, Cell death, Antioxidant
Issue Date: 19-Jan-2016
Citation: CHAN TZE KHEE (2016-01-19). DNA DAMAGE RESPONSES IN AEROALLERGEN-INDUCED ASTHMA. ScholarBank@NUS Repository.
Abstract: ASTHMA IS A CHRONIC INFLAMMATORY DISORDER OF THE AIRWAYS THAT AFFECTS 300 MILLION PEOPLE WORLDWIDE. UP TO 85% OF ASTHMATIC PATIENTS REACT AGAINST HOUSE DUST MITE (HDM), MAKING IT THE MAIN TRIGGER FOR ALLERGIC ASTHMA. IN THIS THESIS, I EMPLOYED A COMPREHENSIVE SET OF ANIMAL MODEL AND BIOCHEMICAL ASSAYS TO STUDY THE DAMAGING EFFECTS OF HDM IN ASTHMA. I REVEALED THE ASSOCIATION BETWEEN INFLAMMATION, OXIDATIVE STRESS AND DNA DAMAGE IN ASTHMATIC AIRWAYS AND SHOWED THAT DNA REPAIR HAS THE POTENTIAL TO MODULATE ASTHMA PROGRESSION. IN ADDITION, I REVEALED THE GENOTOXIC AND CYTOTOXIC POTENTIALS OF HDM IN BRONCHIAL EPITHELIUM, AND HAVE SHOWN A NOVEL ROLE FOR ANTIOXIDANTS IN PREVENTING HDM-INDUCED GENOTOXICITY. I HAVE ALSO DEMONSTRATED THE GENOME PROTECTIVE EFFECTS OF ARTESUNATE IN HDM ASTHMA MODEL. TAKEN TOGETHER, THIS THESIS HIGHLIGHTS THE IMPORTANCE OF DNA DAMAGE AND REPAIR IN ASTHMA-ASSOCIATED PATHOPHYSIOLOGY AND CALLS ATTENTION TO ANTIOXIDANTS AS POTENTIAL MODULATOR OF ASTHMA PATHOGENESIS.
URI: http://scholarbank.nus.edu.sg/handle/10635/124085
Appears in Collections:Ph.D Theses (Open)

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