Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/123946
Title: LOCAL UNFOLDING OF HELICAL PORTAL REGION OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN ALLOWS LIGAND ENTRY FOR BINDING
Authors: XIAO TIANSHU
Keywords: conformational exchange, fatty acid binding protein, local unfolding, protein dynamics, protein structure, disulphide bond
Issue Date: 20-Jan-2016
Source: XIAO TIANSHU (2016-01-20). LOCAL UNFOLDING OF HELICAL PORTAL REGION OF HUMAN INTESTINAL FATTY ACID BINDING PROTEIN ALLOWS LIGAND ENTRY FOR BINDING. ScholarBank@NUS Repository.
Abstract: FATTY ACID BINDING PROTEIN IS IMPORTANT IN LIPID METABOLISM DUE TO THE ABILITY TO BIND WITH FATTY ACIDS AND TRANSPORT THEM TO TARGET SITES. THE MECHANISM UNDERLYING HOW FATTY ACID ENTERS INTO FATTY ACID BINDING PROTEIN REMAINED UNANSWERED FOR TWENTY YEARS. IN THIS STUDY, THE PROCESS OF LIPID ENTRY WAS CLARIFIED BASED ON STRUCTURAL STUDY, DYNAMICS STUDY AND KINETICS STUDY ON THE VARIANT OF HUMAN IFABP, WHICH HAD AN INTRA-MOLECULE DISULPHIDE BOND. IT WAS FOUND THAT FATTY ACID ENTERS THROUGH THE HELICAL PORTAL REGION AFTER THE LOCAL UNFOLDING OF HELIX2.
URI: http://scholarbank.nus.edu.sg/handle/10635/123946
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
XiaoTS.pdf13.73 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

37
checked on Jan 14, 2018

Download(s)

7
checked on Jan 14, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.