Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/123149
Title: DETERMINATION AND TOXICOLOGICAL EVALUATION OF MICROCYSTINS IN TROPICAL RESERVOIRS.
Authors: SHRUTI PAVAGADHI
Keywords: Microcystins, cyanobacteria, zebrafish, toxicology
Issue Date: 24-Aug-2012
Citation: SHRUTI PAVAGADHI (2012-08-24). DETERMINATION AND TOXICOLOGICAL EVALUATION OF MICROCYSTINS IN TROPICAL RESERVOIRS.. ScholarBank@NUS Repository.
Abstract: Microystin-LR (MCLR) and Microcystin-RR (MCRR) are the most commonly found and studied microcystins (MCs) that are produced by blue-green algae (cyanobacteria). Trace levels of these cyanotoxins sustain extracellularly for sufficiently long periods in contaminated water bodies even when the environmental conditions are not favorable for the growth of toxic cyanobacteria. The presence of low doses of MCLR and MCRR could lead to chronic and sub-chronic exposures to the aquatic organisms. As a consequence, there are concerns about the potential health effects of extracellular MCs on organisms living in aquatic ecosystems and thus to humans as well. This doctoral study aimed at determination and toxicological evaluation of extracellular MCs present in reservoirs under tropical conditions using zebrafish as a model organism. Possible implications due to the chronic exposure of MCs are discussed. The study also aimed at identifying possible specific biomarkers.
URI: http://scholarbank.nus.edu.sg/handle/10635/123149
Appears in Collections:Ph.D Theses (Open)

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