Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/122492
Title: MOLECULAR MECHANISMS OF THE PROTO-ONCOGENE BCL6 IN GLIOBLASTOMA
Authors: CHEN YE
Keywords: BCL6, Glioblastoma, ZBTB, TP53, AXL
Issue Date: 29-Jul-2015
Source: CHEN YE (2015-07-29). MOLECULAR MECHANISMS OF THE PROTO-ONCOGENE BCL6 IN GLIOBLASTOMA. ScholarBank@NUS Repository.
Abstract: ZBTB TRANSCRIPTION FACTORS ORCHESTRATE GENE EXPRESSION DURING HUMAN DEVELOPMENT. HOWEVER, THEIR ROLES IN GLIOBLASTOMA MULTIFORME (GBM) REMAIN LARGELY UNEXPLORED. HERE I IDENTIFY BCL6, AN ONCOGENIC PROTEIN IN LYMPHOMA, AS AN IMPORTANT GLIOMA-PROMOTING FACTOR. BCL6 EXPRESSION IS ELEVATED IN AND NECESSARY FOR THE GROWTH OF GBM. BCL6 MODULATES THE EXPRESSION OF TP53, AXL AND MET. THE ACTIVATED BCL6-AXL SIGNALS THROUGH MEK-ERK AND S6K-RPS6 AXES, AND PROMOTES CAP-DEPENDENT TRANSLATION. MOREOVER, DEPLETION OF BCL6 OR PHARMACOLOGICAL INHIBITION OF BCL6/NCOR COMPLEX EFFECTIVELY BLOCKS GBM GROWTH. TOGETHER, THESE FINDINGS UNCOVER A NOVEL GROWTH PROMOTING ROLE OF BCL6 IN GBM, AND PROVIDE THE RATIONALE AND EVIDENCE TO TARGET THIS PROTEIN IN GBM TREATMENT.
URI: http://scholarbank.nus.edu.sg/handle/10635/122492
Appears in Collections:Ph.D Theses (Open)

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