Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/122302
Title: DEVELOPING NOVEL CHEMICAL BIOLOGY TOOLS FOR INTERROGATION OF CELLULAR DRUG TARGETS AT MOLECULAR AND CELLULAR LEVELS
Authors: ZHU BIWEI
Keywords: novel chemical biology tools, ABPP, SMM, cellular drug targets
Issue Date: 5-Aug-2015
Citation: ZHU BIWEI (2015-08-05). DEVELOPING NOVEL CHEMICAL BIOLOGY TOOLS FOR INTERROGATION OF CELLULAR DRUG TARGETS AT MOLECULAR AND CELLULAR LEVELS. ScholarBank@NUS Repository.
Abstract: IN CHEMICAL BIOLOGY, THERE ARE MANY TOOLS WIDELY USED FOR CELL IMAGING, TARGET/INHIBITOR IDENTIFICATION, TARGET SCREENING AND OTHER FUNCTIONS, SUCH AS CHEMICAL PROBES OR MICROARRAY TECHNOLOGY. CHEMICAL PROBES ARE MAINLY FUNCTIONED IN PROTEOME STUDY AND BIO-IMAGING, MOST OF WHICH ARE SELECTIVE AND ACCURATE AT CELLULAR LEVELS; HOWEVER, MICROARRAY IS MAINLY USED IN HIGH THROUGHPUT TARGET SCREENING AND FOLLOWED BY TARGET IDENTIFICATION PROCESSES, WHICH WAS HIGHLY EFFICIENT. IN THIS STUDY, THE DEVELOPMENT OF NOVEL CHEMICAL BIOLOGY TOOLS FOR INTERROGATION OF CELLULAR DRUG TARGETS AT MOLECULAR AND CELLULAR LEVELS WAS MAINLY DISCUSSED; INCLUDING THE DEVELOPMENT OF NEWLY DESIGNED ACTIVITY-BASED PROBES AND AFFINITY-BASED PROBES, AS WELL AS THE NEW APPLICATIONS OF SMALL MOLECULE ARRAY AND CELL-BASED MICROARRAY TECHNOLOGY.
URI: http://scholarbank.nus.edu.sg/handle/10635/122302
Appears in Collections:Ph.D Theses (Open)

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