Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/121928
Title: TARGETED ANTICANCER DRUG DELIVERY USING BIODEGRADABLE AND FUNTIONAL POLYMERIC MICELLES
Authors: KE XIYU
Keywords: polymeric micelles, anticancer drug, delivery, biodegradable, functional, polycarbonate
Issue Date: 21-Aug-2015
Citation: KE XIYU (2015-08-21). TARGETED ANTICANCER DRUG DELIVERY USING BIODEGRADABLE AND FUNTIONAL POLYMERIC MICELLES. ScholarBank@NUS Repository.
Abstract: NANOPARTICLES CAN BYPASS P-GLYCOPROTEIN THAT IS OVEREXPRESSED IN CANCER STEM CELLS (CSCS) AND MULTI-DRUG RESISTANT (MDR) CANCER CELLS, KILLING THESE CELLS MORE EFFECTIVELY THAN FREE DRUGS TO AVOID CANCER RECURRENCE AND METASTASIS. MICELLES HAVE BEEN EXTENSIVELY EXPLORED AS DRUG CARRIER DUE TO THEIR UNIQUE PROPERTIES. IN THIS STUDY, MIXED MICELLES WERE PREPARED BY SELF-ASSEMBLY OF PEG AND ACID/UREA-FUNCTIONALIZED POLYCARBONATE COPOLYMERS FOR CO-DELIVERY OF DOXORUBICIN (DOX) AND THIORIDAZINE FOR TARGETING BOTH CANCER CELLS AND CSCS. TO CIRCUMVENT MDR, TWO PH-SENSITIVE MICELLE SYSTEMS BASED ON DIFFERENT STRATEGIES WERE DESIGNED FOR THE DELIVERY OF DOX. TO OPTIMIZE THE MICELLE FORMULATION, BIODEGRADABLE HYDROPHILIC POLYCARBONATES WERE DESIGNED AND SYNTHESIZED FOR THE REPLACEMENT OF PEG. THESE MICELLES HOLD GREAT POTENTIAL FOR DELIVERY OF ANTICANCER DRUGS TO TARGET BOTH CANCER CELLS AND CSCS, AND TO CIRCUMVENT MDR, AND THE HYDROPHILIC POLYCARBONATES AS PEG ALTERNATIVES ARE PROMISING FOR THE
URI: http://scholarbank.nus.edu.sg/handle/10635/121928
Appears in Collections:Ph.D Theses (Open)

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