Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/121884
Title: INVESTIGATION OF ASYMMETRIC PLATINUM (IV) COMPLEXES AS ANTICANCER PRODRUGS
Authors: CHIN CHEE FEI
Keywords: Cisplatin, Platinum(IV), Prodrug, Anticancer, Asymmetric, Fine-Tuning
Issue Date: 7-Jan-2015
Citation: CHIN CHEE FEI (2015-01-07). INVESTIGATION OF ASYMMETRIC PLATINUM (IV) COMPLEXES AS ANTICANCER PRODRUGS. ScholarBank@NUS Repository.
Abstract: PLATINUM(II) ANTICANCER DRUG CISPLATIN IS ONE OF THE MOST IMPORTANT CHEMOTHERAPEUTIC DRUG IN CLINICAL USE BUT IS LIMITED BY ITS HIGH TOXICITY AND SEVERE SIDE-EFFECTS. PLATINUM(IV) ANTICANCER PRODRUGS CAN OVERCOME THESE LIMITATIONS BY RESISTING PREMATURE AQUATION AND BINDING TO ESSENTIAL PLASMA PROTEINS. CLASSICAL SYMMETRIC PLATINUM(IV) PRODRUG COMPLEXES ARE LIMITED IN THEIR SYNTHETIC UTILITY AS THEIR AXIAL LIGAND SITES FOR FUNCTIONALIZATION ARE IDENTICAL. WE DEVELOPED A NEW CLASS OF ASYMMETRIC PLATINUM(IV) BIS-CARBOXYLATES BASED ON THE CISPLATIN TEMPLATE THROUGH THE STRATEGY OF SEQUENTIAL CARBOXYLATION ON A PLATINUM(IV) HYDROXO PRECURSOR THAT WOULD ALLOW US TO ACCESS PLATINUM(IV) COMPLEXES WITH GREATER STRUCTURAL AND FUNCTIONAL DIVERSITY. WE APPLIED THIS STRATEGY TO DEVELOP FUNCTIONALIZED PLATINUM(IV) PRODRUG COMPLEXES IN THE CONTEXT OF TUNING THEIR PHARMACOLOGICAL PROPERTIES, DEVELOPING PHOTOACTIVATABLE PRODRUG COMPLEXES THAT CAN BE TRIGGERED BY UV IRRADIATION, AS WELL AS ACHIEVING RA
URI: http://scholarbank.nus.edu.sg/handle/10635/121884
Appears in Collections:Ph.D Theses (Open)

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