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Title: | CYCLICAL REGULATION OF A CONTRACTILE TUBE: INSIGHTS FROM THE CAENORHABDITIS ELEGANS SPERMATHECA | Authors: | TAN PEI YI | Keywords: | C. elegans, spermatheca, contractility, SPV-1, mechanotransduction, epithelial tube | Issue Date: | 20-Aug-2015 | Citation: | TAN PEI YI (2015-08-20). CYCLICAL REGULATION OF A CONTRACTILE TUBE: INSIGHTS FROM THE CAENORHABDITIS ELEGANS SPERMATHECA. ScholarBank@NUS Repository. | Abstract: | ACTOMYOSIN CONTRACTILITY IS A MAJOR FORCE DRIVING CHANGES IN TISSUE SHAPE. BIOCHEMICAL SIGNALING PATHWAYS DOWNSTREAM OF RHOA CONTROL ACTIN ASSEMBLY AND NON-MUSCLE MYOSIN II PHOSPHORYLATION, THUS PLAYING AN IMPORTANT ROLE IN REGULATING ACTOMYOSIN CONTRACTILITY. HOWEVER, THE MECHANOTRANSDUCTION PATHWAY FROM TISSUE STRETCHING TO RHOA ACTIVATION IS POORLY UNDERSTOOD. HERE WE SHOW THAT IN C. ELEGANS OVULATION THE F-BAR AND RHOGAP PROTEIN SPV-1 FUNCTIONS TO TRANSDUCE PHYSICAL CUES FROM THE MEMBRANE INTO A BIOCHEMICAL SIGNAL CONTROLLING CONTRACTILITY. SPV-1 LOCALIZES THROUGH ITS F-BAR DOMAIN TO THE APICAL MEMBRANE OF THE RELAXED SPERMATHECA, WHERE IT INHIBITS RHOA ACTIVITY THROUGH ITS RHOGAP DOMAIN. OOCYTE ENTRY FORCES THE SPERMATHECA CELLS TO STRETCH AND SPV-1 DETACHES FROM THE MEMBRANE PERMITTING RHOA ACTIVITY TO INCREASE. THE INCREASE IN RHOA ACTIVITY FACILITATES SPERMATHECA CONTRACTION AND EXPULSION OF THE NEWLY FERTILIZED EMBRYO INTO THE UTERUS. OUR RESULTS DEMONSTRATE HOW MEMBRANE CURV | URI: | http://scholarbank.nus.edu.sg/handle/10635/121642 |
Appears in Collections: | Ph.D Theses (Open) |
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