Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/121342
Title: BIOLOGICAL MARKERS OF PROGNOSTIC IMPORTANCE IN BREAST PHYLLODES TUMOURS
Authors: TAN WAI JIN
Keywords: breast phyllodes tumours, prognosis, nomogram, genetic aberrations, CD117, Six1 Pax3
Issue Date: 9-Jan-2015
Citation: TAN WAI JIN (2015-01-09). BIOLOGICAL MARKERS OF PROGNOSTIC IMPORTANCE IN BREAST PHYLLODES TUMOURS. ScholarBank@NUS Repository.
Abstract: Phyllodes tumours are uncommon fibroepithelial neoplasms of the breast accounting for less than 1% of primary breast tumours. They are classified into benign, borderline and malignant tumours by WHO, based on five histological parameters ? stromal cellularity, stromal atypia, stromal mitoses, presence of stromal overgrowth, and nature of the tumour border. This diagnostic framework remains challenging due to interpretive subjectivity and variable combinational permutations of histological criteria, leading to difficulties in accurate prediction of biological behaviour. In this study, the prognostic importance of clinicopathological parameters and biological markers were investigated. A predictive nomogram estimating recurrence-free survival in phyllodes tumours patients was constructed. Through genome-wide copy number analyses of prognostically distinct groups, chromosomal aberrations were found to be higher in phyllodes tumours which recurred/metastasized, with high-level amplifications and homozygous deletions detected exclusively in these cases. Finally, prognostic importance of CD117, Six1 and Pax3 was evaluated and discussed.
URI: http://scholarbank.nus.edu.sg/handle/10635/121342
Appears in Collections:Ph.D Theses (Open)

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