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|Title:||Iron, neuroinflammation, and Alzheimer's disease|
|Authors:||Ong, W.-Y. |
|Source:||Ong, W.-Y.,Farooqui, A.A. (2005). Iron, neuroinflammation, and Alzheimer's disease. Journal of Alzheimer's Disease 8 (2) : 183-200. ScholarBank@NUS Repository.|
|Abstract:||The present article reviews the roles and interactions of iron and neuroinflammation in Alzheimer's disease. It highlights the importance of neuroinflammatory changes in the glial scar after neuronal injury, in promoting iron accumulation, and iron-dependent oxidative damage. Elevation of iron in Alzheimer's disease not only affects amyloid precursor protein processing and mitochondrial function but also induces the aggregation of Aβ peptide and abnormalities in signal transduction processes associated with oxidative damage. Collective evidence suggests that although alterations in iron homeostasis may not be the primary triggering event that starts the pathological cascade of Alzheimer's disease, it is an important factor involved in neuroinflammation and progression of this disease. © 2005 - IOS Press and the authors. All rights reserved.|
|Source Title:||Journal of Alzheimer's Disease|
|Appears in Collections:||Staff Publications|
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