Please use this identifier to cite or link to this item:
|Title:||Upregulation of nicotinamide adenine dinucleotide phosphate-diaphorase reactivity in the ventral horn motoneurons of lumbosacral spinal cord after urethral obstruction in the guinea pig|
Lumbosacral spinal cord
Ventral horn motoneurons
|Citation:||Zhou, Y., Ling, E.-A. (1997-02-02). Upregulation of nicotinamide adenine dinucleotide phosphate-diaphorase reactivity in the ventral horn motoneurons of lumbosacral spinal cord after urethral obstruction in the guinea pig. Neuroscience Research 27 (2) : 169-174. ScholarBank@NUS Repository. https://doi.org/10.1016/S0168-0102(96)01146-7|
|Abstract:||The role of nitric oxide (NO) in pathophysiology of urethral obstruction in male guinea pig was investigated by using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. In normal and sham-operated control animals, NADPH-d reactivity in the ventral horn motoneurons at L5-L6 and S1-S2 segments of spinal cord was barely detectable or virtually absent. In animals receiving urethral ligation and killed at 6 h after operation, NADPH-d reactivity in the ventral horn motoneurons was comparable to that of control animals. At 12 h, NADPH-d reactivity in the same cells began evident and was markedly enhanced in animals killed at 24 and 48 h. In order to verify whether the increased NADPH-d reactivity was linked to neuronal death, some sections of the lumbosacral spinal cord from urethral obstructed animals were stained in Nissl staining. There was no sign of cell death or atrophy of the ventral horn neurons. Present results suggest the plasticity of NADPH-d in ventral horn neurons which is readily upregulated by urethral ligation. The enhanced NADPH-d reactivity would imply increased nitric oxide synthase (NOS) activity and consequently generation of higher levels of NO in ventral horn neurons. Such alteration maybe involved in distension-induced urethral relaxation in the external urethral sphincter following urethral ligation.|
|Source Title:||Neuroscience Research|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 22, 2019
WEB OF SCIENCETM
checked on Jan 22, 2019
checked on Dec 7, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.