Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00221-002-1045-5
Title: C-fos and c-jun expressions in nitric oxide synthase immunoreactive neurons in the lateral geniculate nucleus of experimental glaucomatous rats
Authors: Wang, X.
Tay, S. 
Ng, Y.-K. 
Keywords: c-fos
c-jun
Glaucoma
Lateral geniculate nucleus
nNOS
Issue Date: 2002
Citation: Wang, X., Tay, S., Ng, Y.-K. (2002). C-fos and c-jun expressions in nitric oxide synthase immunoreactive neurons in the lateral geniculate nucleus of experimental glaucomatous rats. Experimental Brain Research 144 (3) : 365-372. ScholarBank@NUS Repository. https://doi.org/10.1007/s00221-002-1045-5
Abstract: The present study was initiated to investigate the expressions of c-fos and c-jun in nitric oxide synthase immunoreactive neurons and their possible roles in the lateral geniculate nucleus (LGN) of glaucomatous rats. An experimental one-eye glaucoma model was created by cauterisation of the limbal-derived veins. Animals were killed by cardiac perfusion, and brains containing the LGN were removed and processed for c-fos, c-jun and neuronal nitric oxide synthase (nNOS) immunohistochemistry. No c-fos or c-jun immunoreactivity was observed in the LGN of control rats. In the glaucomatous rats, expression of c-fos and c-jun was induced bilaterally in the ventral LGN (vLGN) as early as 2 h postoperation. The number of c-fos-immunopositive cells increased at 1 and 2 days postoperation in both the lateral and medial subdivisions of the vLGN (vLGN-l and vLGN-m). Thereafter, the expression decreased and was totally absent at 1 and 2 weeks. No c-fos was induced in the dorsal LGN (dLGN). C-jun-immunopositive cells were mainly localised in the intergeniculate leaflet and vLGN. Few neurons were observed in the dLGN. The number of c-jun-immunopositive cells decreased at 1 and 2 weeks postoperation. Some of the c-fos- and c-jun-immunopositive cells were also nNOS immunopositive. The present results reveal that glaucoma activates the expressions of immediate early genes (IEGs) in some cells of the LGN. It is postulated that they may play important roles in the pathologic processes of glaucoma. The relationship between these IEGs and nitric oxide was also discussed.
Source Title: Experimental Brain Research
URI: http://scholarbank.nus.edu.sg/handle/10635/120728
ISSN: 00144819
DOI: 10.1007/s00221-002-1045-5
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