Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/120412
Title: THE ROLE OF AUTOCRINE HUMAN GROWTH HORMONE IN COLORECTAL CANCER PROGRESSION
Authors: WANG JINGJING
Keywords: human growth hormone, colorectal cancer, oncogenicity, EMT, metastasis, cancer stem cell
Issue Date: 20-Aug-2014
Citation: WANG JINGJING (2014-08-20). THE ROLE OF AUTOCRINE HUMAN GROWTH HORMONE IN COLORECTAL CANCER PROGRESSION. ScholarBank@NUS Repository.
Abstract: The functional role of human growth hormone (hGH) in the progression of cancer has been extensively studied. However, the specific functional role of hGH in colorectal cancer (CRC) remains largely to be determined. By use of CRC cell lines, I demonstrated that autocrine hGH promoted oncogenicity and EMT in CRC cell. Autocrine hGH stimulated oncogenicity and EMT in CRC cells through MAPK/ERK pathway. Additionally, the loss of E-CADHERIN and the increase of FN1 were required for the autocrine hGH-stimulated CRC cell migration and invasion. Furthermore, autocrine hGH promoted tumor growth and local invasion of CRC cells in xenograft models in vivo. Moreover, autocrine hGH stimulated cancer stem cell (CSC)-like behavior in CRC cells in a E-CADHERIN-dependent manner. The results described in this thesis demonstrated the functional role of autocrine hGH in CRC progression, suggesting that inhibition of hGH function in CRC may provide some benefit to patients with CRC.
URI: http://scholarbank.nus.edu.sg/handle/10635/120412
Appears in Collections:Ph.D Theses (Open)

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