Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/120128
Title: DYNAMIC BINDING KINETICS STUDY OF MALARIA INFECTED RED BLOOD CELL
Authors: XU XIAOFENG
Keywords: malaria, flow, microfluidic, plasmodium falciparum, CD36, chloroquine
Issue Date: 22-Aug-2014
Source: XU XIAOFENG (2014-08-22). DYNAMIC BINDING KINETICS STUDY OF MALARIA INFECTED RED BLOOD CELL. ScholarBank@NUS Repository.
Abstract: Cytoadherence of plasmodium falciparum infected red blood cell to endothelial cells plays an important role in malaria pathogenesis. In this thesis, we developed a flow based protocol to study the binding kinetics of infected red blood cell adhesion to CD36 endothelial protein under shear flow. Using this device, firstly, we experimentally demonstrated the bistability property of infected red blood cell adhesion under shear flow and subsequently we quantitatively investigated different parameters involved in the binding process under flow, such as contact area and deformability of infected red blood cells at different stages of infection. Finally, we studied chloroquine effects on the cytoadherence of the infected red blood cell under shear flow and explored the factors that may contribute to chloroquine resulted biomechanical change.
URI: http://scholarbank.nus.edu.sg/handle/10635/120128
Appears in Collections:Ph.D Theses (Open)

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