Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/120118
Title: RETINAL IMAGING IN CEREBROVASCULAR DISEASE AND DEMENTIA
Authors: ONG YI TING
Keywords: retinal imaging, stroke, dementia, cerebrovascular disease, mild cognitive impairment
Issue Date: 15-Jan-2015
Source: ONG YI TING (2015-01-15). RETINAL IMAGING IN CEREBROVASCULAR DISEASE AND DEMENTIA. ScholarBank@NUS Repository.
Abstract: The retina provides a unique window to observe early microvascular and neuronal damage in association with cerebrovascular disease and dementia. Retinal microvascular abnormalities have been linked to stroke, dementia, cerebral atrophy and small vessel disease. Nerve defects have been linked to Alzheimer?s disease (AD). Novel parameters quantifying the microvascular network and neuronal layers of the retina have been proposed as potential markers for early microvascular and neurodegenerative pathology in stroke and dementia. In this thesis, advanced retinal imaging and analytic techniques for the assessment of the retinal microvascular network and neuronal layers will be applied in epidemiological studies of varying designs to demonstrate the following: (1) Retinal vascular parameter changes are associated with ischemic stroke, cerebral small vessel disease, cognitive impairment, AD and vascular dementia; (2) Thinning of the retinal neuronal layers is associated with cerebral atrophy, preclinical dementia, AD and vascular dementia.
URI: http://scholarbank.nus.edu.sg/handle/10635/120118
Appears in Collections:Ph.D Theses (Open)

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