Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/120115
Title: INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS: THE ROLES OF ANNEXIN A1 PROTEIN AND CLEC9A+ DENDRITIC CELLS
Authors: KOH HUI QI VANESSA
Keywords: immunology, tuberculosis, annexin A1, dendritic cells, clec9A, mycobacterium tuberculosis
Issue Date: 13-Jan-2015
Source: KOH HUI QI VANESSA (2015-01-13). INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS: THE ROLES OF ANNEXIN A1 PROTEIN AND CLEC9A+ DENDRITIC CELLS. ScholarBank@NUS Repository.
Abstract: Tuberculosis (TB) has been declared a global public health emergency by the World Health Organization since 1993. Despite international control programmes, the worldwide burden of TB remains enormous, fuelled by emergent drug-resistant strains and HIV co-infection. Efforts to discover novel drugs have largely been focused on targeting the bacterium directly. Alternatively, manipulating the host response to TB infection may represent a valuable approach to help the host immune system clear the bacilli more effectively and more rapidly. However, such an approach necessitates a better understanding of the immune mechanisms associated with protection against TB. In this context, we embarked on studying two aspects of host immunity to M. tuberculosis infection: the role of Annexin A1, a protein expressed endogenously by a variety of immune cells, and the role of the Clec9A+ dendritic cell (DC) subset, which includes CD103+ migratory DCs in the lung and CD8+ DCs in the lymphoid organs.
URI: http://scholarbank.nus.edu.sg/handle/10635/120115
Appears in Collections:Ph.D Theses (Open)

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