Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119890
Title: STUDIES ON THE REGULATORY ROLES OF MICRORNA-27A AND MICRORNA-200B IN ACTIVATED RODENT MICROGLIA
Authors: SHWETA PRADIP JADHAV
Keywords: miRNAs, microglia, inflammation, CNS, MAPK, TGFB
Issue Date: 21-Jan-2015
Source: SHWETA PRADIP JADHAV (2015-01-21). STUDIES ON THE REGULATORY ROLES OF MICRORNA-27A AND MICRORNA-200B IN ACTIVATED RODENT MICROGLIA. ScholarBank@NUS Repository.
Abstract: Chronic activation of microglia, the macrophages of the Central Nervous system (CNS), results in exaggeration of the neuronal damage in CNS pathologies including Alzheimer?s disease, Parkinson?s disease or brain injury. Thus, understanding the mechanism of microglia-mediated inflammation is crucial towards developing neurodegenerative disease therapies. Epigenetic factors such as miRNAs are known to regulate microglial functions. To catalogue the miRNA changes contributing to microglial activation, a global miRNA microarray was carried out using control and activated primary microglia (by LPS or A?). This screen identified several differentially expressed miRNAs in activated microglia. Two miRNAs were chosen for further study- 1) miR-27a, upregulated in activated microglia, mediating microglial activation by suppression of the TGF? signaling pathway 2) miR-200b, repressed in activated microglia, mediating microglial quiescence by downregulating the cJun/JNK pathway. It is concluded that miRNAs altered different aspects of microglial functions including inflammatory response, migration and neuronal survival by regulating the TGF? and JNK signaling pathways in microglia.
URI: http://scholarbank.nus.edu.sg/handle/10635/119890
Appears in Collections:Ph.D Theses (Open)

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