Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119473
Title: THE ROLE OF TREFOIL FACTOR 3 IN MAMMARY CARCINOMA ANGIOGENESIS
Authors: LAU WAI HOE
Keywords: Trefoil factor 3, angiogenesis, mammary carcinoma, interleukin 8, STAT3
Issue Date: 22-Aug-2014
Citation: LAU WAI HOE (2014-08-22). THE ROLE OF TREFOIL FACTOR 3 IN MAMMARY CARCINOMA ANGIOGENESIS. ScholarBank@NUS Repository.
Abstract: MAMMARY CARCINOMA CELLS RELEASE VARIOUS ANGIOGENIC FACTORS THAT STIMULATE ENDOTHELIAL CELLS TO PROMOTE ANGIOGENESIS. TREFOIL FACTOR 3 (TFF3) IS INVOLVED IN PROTECTION OF THE GASTROINTESTINAL TRACT AGAINST MUCOSAL DAMAGE. INCREASED TFF3 EXPRESSION PROMOTES ONCOGENICITY AND INVASIVENESS OF MAMMARY CARCINOMA CELLS. HOWEVER, THE ROLE OF TFF3 IN MAMMARY CARCINOMA ANGIOGENESIS HAS NOT YET BEEN DETERMINED. HEREIN, I HAVE DEMONSTRATED THAT TFF3 SECRETED FROM MAMMARY CARCINOMA CELLS PROMOTED ANGIOGENIC BEHAVIORS OF HUVEC. MAMMARY CARCINOMA CELLS WITH FORCED EXPRESSION OF TFF3 PRODUCED TUMORS WITH INCREASED MICROVESSEL DENSITY AS COMPARED TO TUMORS FORMED BY CONTROL CELLS IN XENOGRAFT MODELS. DEPLETION OF TFF3 IN MAMMARY CARCINOMA CELLS BY SIRNA DIMINISHED ANGIOGENIC BEHAVIORS OF HUVEC. MECHANISTICALLY, TFF3 PROMOTED ANGIOGENESIS IN MAMMARY CARCINOMA THROUGH ACTIVATION OF STAT3-IL-8 SIGNALING. HENCE, TFF3 IS A PROMOTER OF TUMOR ANGIOGENESIS, WHICH MAY CO-COORDINATE WITH THE GROWTH PROMOTING AND
URI: http://scholarbank.nus.edu.sg/handle/10635/119473
Appears in Collections:Ph.D Theses (Open)

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