Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119394
Title: CHARACTERIZATION OF MONOCYTES IN PEDIATRIC MINIMAL CHANGE NEPHROTIC PATIENTS
Authors: YEO WEE SONG
Keywords: Characterization, Monocytes, Pediatric, Minimal Change Nephrotic
Issue Date: 22-Sep-2014
Source: YEO WEE SONG (2014-09-22). CHARACTERIZATION OF MONOCYTES IN PEDIATRIC MINIMAL CHANGE NEPHROTIC PATIENTS. ScholarBank@NUS Repository.
Abstract: INTERLEUKIN 13 (IL-13) EXPRESSION WAS PREVIOUSLY NOTED TO BE UPREGULATED IN CD4+ AND CD8+ T-CELLS OF MINIMAL CHANGE NEPHROTIC SYNDROME (MCNS) PATIENTS IN RELAPSE COMPARED TO REMISSION/CONTROLS. IL-13 AS A KEY MEDIATOR IN MCNS PATHOGENESIS WAS FURTHER REINFORCED IN OUR IL-13 OVEREXPRESSED RAT MODEL WHICH SHOWED MINIMAL CHANGE-LIKE NEPHROPATHY. AS IL-13 IS A KNOWN MONOCYTE MODULATOR AND THE MULTIPLE ASSOCIATIONS OF MONOCYTES WITH MCNS, CHARACTERIZATION OF MONOCYTES IN MCNS PATIENTS WAS PERFORMED. MCNS PATIENTS IN RELAPSE WERE NOTED TO HAVE A HIGHER PROPORTION OF `RESIDENT? MONOCYTES COMPARED TO REMISSION, INDICATIVE OF AN IL-13 INDUCED POLARIZATION STATE. MONOCYTES OF MCNS PATIENTS IN RELAPSE ALSO SHOWED DECREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES POST-LPS STIMULATION. THESE FINDINGS WERE FURTHER DEMONSTRATED IN THE MICROARRAY STUDY AND CONSISTENT WITH FINDINGS IN THE IL-13 OVEREXPRESSED RAT MODEL, SUGGESTING A CRUCIAL ROLE OF MONOCYTES IN MCNS PATHOGENESIS AND PREDISPOSITION TOWA
URI: http://scholarbank.nus.edu.sg/handle/10635/119394
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
YeoWS.pdf20.95 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

84
checked on Jan 20, 2018

Download(s)

13
checked on Jan 20, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.