Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119392
Title: IMMUNOPATHOGENESIS OF DENGUE VIRUS INFECTION
Authors: CHEN JINCHENG
Keywords: Dengue, TLR6, TLR2, IL-6, TNF, NS1
Issue Date: 12-Sep-2014
Source: CHEN JINCHENG (2014-09-12). IMMUNOPATHOGENESIS OF DENGUE VIRUS INFECTION. ScholarBank@NUS Repository.
Abstract: TOLL-LIKE RECEPTOR (TLR) 2 AND TLR6 WERE FOUND TO BE UP-REGULATED IN DV-INFECTED HUMAN PBMC. IL-6 AND TNF-A, CYTOKINES DOWNSTREAM OF TLR2 AND TLR6 SIGNALING PATHWAYS WERE ALSO FOUND TO BE UP-REGULATED IN DV-INFECTED PBMC. IL-6 AND TNF-A PRODUCTION BY PBMC WERE REDUCED WHEN TLR2 AND TLR6 WERE BLOCKED DURING DV INFECTION, SUGGESTING THAT SIGNALING PATHWAYS OF TLR2 AND TLR6 WERE ACTIVATED DURING DV INFECTION. DENGUE NS1 PROTEIN WAS FOUND TO SIGNIFICANTLY INCREASE THE PRODUCTION OF IL-6 AND TNF-A WHEN ADDED TO PBMC. IL-6 AND TNF-A STIMULATED BY DENGUE NS1 PROTEIN WERE REDUCED WHEN TLR2 AND TLR6 WERE BLOCKED, SUGGESTING THAT DENGUE NS1 PROTEIN IS THE VIRAL PROTEIN RESPONSIBLE FOR THE ACTIVATION OF TLR2 AND TLR6 DURING DV INFECTION. DV-INFECTED TLR6-/- MICE HAVE HIGHER SURVIVABILITY COMPARED TO DV2-INFECTED WILD-TYPE MICE. HENCE, ACTIVATION OF TLR6 VIA DENGUE NS1 PROTEIN COULD POTENTIALLY PLAY AN IMPORTANT ROLE IN THE IMMUNOPATHOGENESIS OF DV INFECTION.
URI: http://scholarbank.nus.edu.sg/handle/10635/119392
Appears in Collections:Ph.D Theses (Open)

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