Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119245
Title: The Role of Hydrogen Sulfide in the Central Nervous System: Implications in the Treatment of Alzheimer's Disease
Authors: BHUSHAN VIJAY NAGPURE
Keywords: hydrogen sulfide, alzheimer's disease, amyloid
Issue Date: 22-Aug-2014
Citation: BHUSHAN VIJAY NAGPURE (2014-08-22). The Role of Hydrogen Sulfide in the Central Nervous System: Implications in the Treatment of Alzheimer's Disease. ScholarBank@NUS Repository.
Abstract: Alzheimer?s disease (AD) is the most common neurodegenerative disease. In this thesis, beneficial effects of hydrogen sulfide (H2S) were studied in AD pathology. H2S pretreatment was found to inhibit A?42 synthesis SH-SY5Y cells transfected with APP Swedish mutation. The downregulation of ?-secretase via blocking intracellular cAMP dependent cascade was the underlying pathway. H2S-inhibited cAMP production was also responsible for its regenerative effect on glutamate uptake and restoration of GLAST in primary astrocytes. Severe neuroinflammation leads to amyloidogenesis in the CNS. H2S pretreatment suppressed extracellular ATP-induced severe neuroinflammation and consequent A? synthesis in BV-2 microglia cells. H2S sulhydrated cys-25 in Cathepsin S, downregulating its activity along with those of NF-?B and STAT3. It culminated in lowered transcription of inflammatory genes and amyloidogenic APP cleavage. In conclusion, H2S therapy can be a promising therapeutic strategy against AD as it acts on the multiple targets in the pathology.
URI: http://scholarbank.nus.edu.sg/handle/10635/119245
Appears in Collections:Ph.D Theses (Open)

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