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Title: Epigenetic Control of Neuronal Activity-dependent Gene Transcription as a Basis for Long-Term Memory Formation
Keywords: epigenetics, brain, neuronal activity-regulated genes, memory formation
Issue Date: 26-Feb-2015
Source: NICODEMUS EDRICK OEY (2015-02-26). Epigenetic Control of Neuronal Activity-dependent Gene Transcription as a Basis for Long-Term Memory Formation. ScholarBank@NUS Repository.
Abstract: The brain is a highly plastic structure, capable of changing its response depending on the external stimuli it receives. This evolutionarily conserved concept of neuroplasticity underlies all forms of memory, from flies to humans. While short-term memories that last for minutes are mediated by transient changes in neural connections, long-term memories that last for years require more persistent changes including the production of new proteins. Neuronal activity-dependent gene transcription is mediated by complex mechanisms collectively known as epigenetic processes, the importance of which is strongly demonstrated by the disastrous consequences of their absence in various clinical syndromes of mental retardation. Using a combination of cutting-edge super-resolution microscopy, mass spectrometry, and transcriptomics, the present work attempts to study and characterize the events that mediate long-term memory consolidation from an epigenetics standpoint, specifically in chromatin modification which seems to be involved in all aspects of memory formation and consolidation.
Appears in Collections:Ph.D Theses (Open)

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