Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/119036
Title: ROLE OF TRANSCRIPTION FACTORS, RUNXITI AND PPAR? AND A HERBAL COMPOUND COSTUNOLIDE IN MODULATING THE ACTIVATION OF RODENT MICROGLIA
Authors: NIMMI BABY
Keywords: Microglia, Runx1t1, Cdk4, LAT2, HDACs, Costunolide
Issue Date: 6-Mar- 15
Source: NIMMI BABY (0015-03-06). ROLE OF TRANSCRIPTION FACTORS, RUNXITI AND PPAR? AND A HERBAL COMPOUND COSTUNOLIDE IN MODULATING THE ACTIVATION OF RODENT MICROGLIA. ScholarBank@NUS Repository.
Abstract: Microglia, the resident immune cells of the brain, undergo rapid proliferation and produce toxic molecules when activated in neuropathologies. This study is mainly focused on identifying the role of trnscription factors such as Runt-related transcription factor 1; translocated to 1 (Runx1t1) and Peroxisome Proliferator Activated Receptor ? (PPAR?) in modulating the activation of microglia, and on elucidating the mechanism of action of Costunolide, a herbal compound on the inflammatory reactions of activated microglia after traumatic brain injury. It has been shown that Runx1t1 controls the proliferation and neurotoxic effect of microglia by epigenetically regulating Cdk4 and L-aminoacid transporter-2 (LAT2) via its interaction with histone deacetylases (HDACs). Further, this study confirmed that Costunolide delivers its inhibitory effects on microglia by binding and activating PPAR?, an inhibitor of NFkB signaling pathway.
URI: http://scholarbank.nus.edu.sg/handle/10635/119036
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormat 
Baby. N. PDF.pdf5.31 MBAdobe PDFView/Download

Page view(s)

109
checked on Nov 17, 2017

Download(s)

36
checked on Nov 17, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.